Pharmaceuticals News -- ScienceDaily
When given the chance to pay less, patients choose cheaper prescription drugs
As prescription drug spending continues to rise in the United States, along with prices for new and well-established drugs, insurers, employers and patients are searching for ways to cut costs. A new study found that a policy called reference pricing is effective at encouraging patients to spend significantly less on prescription drugs by choosing cheaper drugs over name brand options.
Gut-on-chip good predictor of drug side-effects
Research has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body.
Once invincible superbug squashed by 'superteam' of antibiotics
A team of three antibiotics has been assembled that, together, are capable of eradicating E. coli carrying mcr-1 and ndm-5 -- genes that make the bacterium immune to last-resort antibiotics, report researchers.
Licorice is a hot trend in hot flashes, but could interact with medications
Licorice roots have a flavorful history, having been used in ancient Egyptian teas and in traditional Chinese medicines, all the way to today as a flavoring agent and candy. And some women now take licorice extracts as supplements to treat menopausal symptoms. But scientists caution that licorice could pose a health risk by interacting with medications.
New vaccine could someday fight the effects of opioid combinations
Substance abuse is a continuing problem in the US, to the point of being an 'epidemic.' Treatments exist, but far too often patients relapse with devastating impacts on themselves and those around them. Now, scientists report that they have made progress toward a vaccine against the effects of fentanyl, a synthetic opioid, in combination with heroin.
Data revealed under FOI shows benefits of MS drug currently blocked by regulators
A drug that is blocked by the EU regulatory system has now been found to improve the quality of life of people with multiple sclerosis (MS), according to a new study.
Cigarette makers shifted stance on nicotine patches, gum, study shows
Tobacco companies have known for decades that, without counseling, NRT hardly ever works, and that consumers often use it to complement smoking. This insight from the formerly secret industry documents, outlines a new report.
Slowing dangerous bacteria may be more effective than killing them
A new study suggests it may be possible to slow dangerous infections by manipulating the messages microbes send to one another, allowing the body to defeat an infection without causing the bacteria to develop resistance to the treatment.
Combination of traditional chemotherapy, new drug kills rare cancer cells in mice
An experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and prevented a recurrence within 300 days, a study found.
Chewing gum rapid test for inflammation
Dental implants occasionally entail complications: Six to fifteen percent of patients develop an inflammatory response in the years after receiving a dental implant. This is caused by bacteria destroying the soft tissue and the bone around the implant in the worst case.
Drug-delivering micromotors treat their first bacterial infection in the stomach
Nanoengineers have demonstrated, for the first time, using micromotors to treat a bacterial infection in the stomach. These tiny vehicles, each about half the width of a human hair, swim rapidly throughout the stomach while neutralizing gastric acid and then release their cargo of antibiotics at the desired pH.
Compounds in desert creosote bush could treat giardia, 'brain-eating' amoeba infections
Researchers have found that compounds produced by the creosote bush, a desert plant common to the Southwestern United States, exhibit potent anti-parasitic activity against the protozoa responsible for giardia infections and an amoeba that causes an often-lethal form of encephalitis.
'Accelerated approval' drugs: How well are they studied£
Researchers have examined the pre-approval and post-approval clinical trials of drugs granted FDA Accelerated Approval between 2009 and 2013.
Does stronger initial response to cancer treatment predict longer overall survival£
It seems like such a simple question: Do patients whose tumors shrink more in response to targeted treatment go on to have better outcomes than patients whose tumors shrink less£ But the implications of a recent study demonstrating this relationship are anything but simple and could influence both the design of future clinical trials and the goals of oncologists treating cancer.
Weight-gain receptor linked to antipsychotic drugs, report researchers
Many schizophrenic and depressed patients experience weight gain and type 2 diabetes in their quests for the life-changing benefits of a major class of antipsychotic drugs. Now researchers may know why.
Drug approval: New country comparison shows great savings potential
The regulatory requirements for the approval of new drugs vary greatly internationally in regards to the resources allocated to the authorities, the evaluation periods for approval and the fees for the pharmaceutical companies.
Small molecule inhibitor prevents or impedes tooth cavities in a preclinical model
Researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecular sabotage that is akin to throwing a monkey wrench into machinery to jam the gears.
Ultrasound-triggered liposomes for on-demand, local anesthesia
A new way to non-invasively relieve pain at local sites in the body has now been identified. Such systems could one day improve pain management by replacing addictive opioids and short-lasting local anesthetics, say researchers.
One in twelve doctors accepts payment from pharmaceutical companies related to opioids
One in twelve physicians -- and nearly one in five family medicine physicians -- accepted payments from pharmaceutical companies related to opioids, according to a new study.
Crystallography provides battle-plan blueprints for attacking disease-causing bacteria
X-rays helped scientists to look under the bonnet of two common bacteria that opportunistically infect people, so as to better understand the mechanics involved. The blueprints may be used to design new drugs, which are badly needed.
Improving detection of a 'date rape' drug
Because gamma hydroxybutyric acid (GHB), commonly known as a 'date rape drug' is rapidly absorbed and metabolized by the body, it's difficult for law enforcement to tell if someone has been given GHB. Now, scientists report that they have identified a potential biomarker that might lead to tests to detect the compound that could be performed much later than current ones.
Biomaterial delivers both a powerful drug and gene silencers
Clinicians today have a huge arsenal of drugs at their disposal for treating cancers. But many chemotherapeutic agents pose stubborn challenges: they cause serious side effects, some cancers develop resistance, and many chemotherapies demonstrate low bio-availability. A potential solution lies in the synergistic combination of a chemotherapeutic drug with engineered genetic material. New hybrid materials combine a lipid 'container' for transfection and a protein capsule to deliver a chemical one-two punch.
'Killer peptide' discovered that helps eliminate resistant cancer cells
When therapy-sensitive cancer cells die, they release a 'killer peptide' that can eliminate therapy-resistant cells, new research indicates.
A surprising new role for baker's yeast
Baker's yeast is best known for its role in baking and brewing beer. But, thanks to new research, we now know that this humble organism can be used in leading edge drug discovery.
Even bacteria have baggage, and understanding that is key to fighting superbugs
New research points to treatment strategies for multi-drug antibiotic resistance using currently available drugs. The study demonstrates how different adaptation histories of bacterial pathogens to antibiotics leads to distinct evolutionary dynamics of multi-drug resistance.
First-in-class drug holds promise for therapy-resistant breast cancer
A first-in-class molecule can prevent breast cancer growth when traditional therapies stop working, new research indicates.
New antibiotic class found effective against gonorrhea in the laboratory
Closthioamide, discovered in 2010, might eventually offer an alternative for current drugs that are becoming less effective against gonorrhoea, report investigators.
New approach makes it easier to find novel drugs
Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases.
Compound derived from marijuana interacts with antiepileptic drugs
New research suggests that an investigational neurological treatment derived from cannabis may alter the blood levels of commonly used antiepileptic drugs.
More accurate estimates of state opioid and heroin fatalities
A new study presents a correction procedure to refine data reporting opioid and heroin deaths per US state, which results in significant shifts in state-by-state mortality rates. This truer picture helps to remove an important barrier to formulating effective policies to address this serious drug epidemic.
New, more sensitive sensor for evaluating drug safety
A new technique for evaluating drug safety is designed to be affordable and can detect stress on cells at earlier stages than conventional methods. It is the first with a fluorescent sensor that turns on when proteins begin to clump together -- an early sign of a process that occurs in Alzheimer's and other diseases.
Diabetes drug shows potential as disease-modifying therapy for Parkinson's disease
A drug commonly used to treat diabetes may have disease-modifying potential to treat Parkinson's disease, a new study suggests, paving the way for further research to define its efficacy and safety.
Bioprinted veins reveal new drug diffusion details
A new advance now offers the ability to construct vascularized tissue and mimic in vivo drug administration in 3-D bioprinted liver tissue. Scientists developed this relatively simple liver model to offer a more accurate system for drug toxicity testing.
Of mice and cheeseburgers: Experimental drug reverses obesity-related liver disease
An experimental drug protected mice from one of the many ills of our cheeseburger and milkshake-laden Western diet -- non-alcoholic fatty liver disease. The drug reversed liver inflammation, injury and scarring in animals fed a high fat, sugar and cholesterol diet. The diet was designed to replicate the Western fast food diet and recreate the features of non-alcoholic fatty liver disease found in people. The research team plans further testing to move it into human trials.
Arthritis drug could treat blood cancer patients, breakthrough finds
A drug used for arthritis could be used to treat blood cancer, scientists have found. Polycythemia vera, a type of blood cancer, affects 3,000 people a year. This breakthrough offers an affordable and effective treatment, say the investigators.
Prediciting TB's behavior
When it comes to predicting response to treatment and risk of dying, molecular tests that detect resistance to a class of TB drugs known as fluoroquinolones may be as good and even superior to traditional drug-sensitivity tests conducted in lab cultures, new research shows.
How to reprogram cells in our immune system
Scientists have revealed, for the first time, a method to reprogram specific T cells. More precisely, they discovered how to turn pro-inflammatory cells that boost the immune system into anti-inflammatory cells that suppress it, and vice versa.
Increasing risk of drug withdrawal in newborns as US opioid epidemic accelerates
Taking a combination of opioids (strong prescription painkillers) and psychotropic medications (widely used to treat mental health conditions such as anxiety and depression) during pregnancy is associated with a greater risk of drug withdrawal in newborns, finds a study.
Three Klebsiella species cause life-threatening infections and share drug resistance genes
Three different species of Klebsiella bacteria can cause life-threatening infections in hospital patients and that all three share genes that confer resistance to the most commonly used antibiotics, new research shows. The study improves physicians' understanding of Klebsiella infections and could point toward better ways to fight multi-drug resistant strains of these bacteria.
Lighting the way: Sensors show drug uptake
When designing and characterizing new drugs, a key aspect is making sure the drug actually goes where it is intended to. But current tests for drug uptake monitor the process under unrealistic conditions and do not provide information on the amounts of drugs that cross into a cell. Now, one group reports that fluorescent detector proteins can overcome these challenges.
'Antibiotic stewardship teams' must be planned and paid for to halt dangerous infections
There is an urgent need to plan and fund teams of specialist health workers to promote appropriate use of antibiotics, according to an expert.
New drug may treat and limit progression of Parkinson's disease
Researchers have developed a new drug that may limit the progression of Parkinson's disease while providing better symptom relief to potentially hundreds of thousands of people with the disease.
New drug therapy targets in a range of diseases
Scientists have a better understanding of the immune system at a molecular level, thanks to research that may now lead to a range of new treatments for disease. The research provides a new foundation for therapeutic strategies against a wide range of diseases and infections.
Novel thermal ablation system for transdermal drug delivery
The size of protein-based drug molecules prevents their absorption into the body when taken orally making injection (intramuscularly, subcutaneously, intravenously, etc.) the only effective delivery method. Research into transdermal drug delivery systems to make taking these drugs easier and cheaper has lead researchers to develop a new transdermal thermal abrasion system. It uses near-infrared light to irradiate gold nanorods in a gel skin patch to increase skin permeability for improved drug delivery.
Seeing more with PET scans: New chemistry for medical imaging
Researchers have found a surprisingly versatile workaround to create chemical compounds that could prove useful for medical imaging and drug development.
Compound shows promise in treating melanoma
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.
Scientists propose novel therapy to lessen risk of obesity-linked disease
With obesity related illnesses a global pandemic, researchers propose using a blood thinner to target molecular drivers of chronic metabolic inflammation in people eating high-fat diets to limit weight gain and disease.
Scientists enlist baker's yeast in a hunt for new medicines
Scientists have come up with a new way to predict potentially useful drugs from a pool of undefined chemicals. They were able to more quickly identify leads that could be used to treat a range of diseases, from infections, to cancer to Alzheimer's. The finding will also help better match drugs to a disease to maximize the benefit and reduce side-effects.
Drug interaction concerns may affect HIV treatment adherence among transgender women
Transgender women -- at high risk of HIV acquisition -- are a key population for HIV prevention and treatment efforts. A new study reveals that more than half of transgender living with HIV in Los Angeles were concerned that taking both antiretroviral therapy to treat HIV and feminizing hormone therapy (HT) may cause harmful drug-drug interactions. Many surveyed cited these concerns as a reason for not taking anti-HIV medications, HT, or both.
Hopes high to slash the number of deaths from killer fungal disease in Africa
Experts aim to halve the number of deaths from cryptococcal meningitis by changing drug treatment programmes after the results of a new medical trial.
Immune cells the missing ingredient in new bladder cancer treatment
New research offers a possible explanation for why a new type of cancer treatment hasn't been working as expected against bladder cancer.
Alternative antimicrobial compounds could come from wastewater
Municipal wastewater may become a key ally in the fight against antibiotic-resistant disease-causing bacteria and fungi, a new study has found.
High levels of antibiotic-resistance in Indian poultry farming raises concerns
A new study from India raises questions about the dangers to human health of farming chicken with growth-promoting antibiotics -- including some of the same drugs used in raising millions of chickens in the United States and worldwide.
Despite lack of efficacy data, surprising consensus in pediatric anti-epilepsy med scripts
A new study indicates that US doctors appear to have reached an unexpected consensus about which anti-seizure medicine to prescribe to their pediatric patients.
Novel CRISPR-Cas9 screening enables discovery of new targets to aid cancer immunotherapy
A novel screening method using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice has revealed new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer immunotherapy. Research shows deletion of the Ptpn2 gene in tumor cells made them more susceptible to PD-1 checkpoint inhibitors.
Switch to generic eye drugs could save Medicare millions
Eye care providers prescribe more brand medications by volume than any other provider group, according to a new study, making ophthalmologist and optometrists big influencers of annual prescription drug spending in the United States.
'Superbugs' study reveals complex picture of E. coli bloodstream infections
The first large-scale genetic study of Escherichia coli (E. coli) cultured from patients with bloodstream infections in England showed that drug resistant 'superbugs' don't always out-compete other strains. Research has shown that new types of E. coli occur frequently, but unlike in some other infections, drug-resistant strains do not become a dominant cause of infection.
Optimal methods for administering children's medications
New research aims to help solve the problem of dose optimization of children's medicines.
New combination of anti-obesity drugs may have beneficial effects
New research has revealed that a unique combination of hormone-based drugs can produce enhanced weight loss in laboratory tests with obese animals.
Rare disease clues found in cell's recycling system
Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1). They found that a closely related compound will activate an enzyme, AMPK, triggering a cellular 'recycling' system that helps reduce elevated cholesterol and other accumulated fats in the brains and livers of NPC1 patients, which are hallmarks associated with severe neurological problems.
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