Pharmaceuticals News -- ScienceDaily
Anti-epilepsy drug restores normal brain activity in mild Alzheimer's disease
An anti-epileptic drug has been tested for its potential impact on the brain activity of patients with mild Alzheimer's disease. The team documented changes in patients' EEGs that suggest the drug could have a beneficial effect.
Similarities between next-generation prostate cancer drugs discovered
For the first time, researchers have shown how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings may lay the foundation for improving therapies for treatment-resistant, aggressive prostate cancer.
New inhibitor drug shows promise in relapsed leukemia
A new drug shows promise in its ability to target one of the most common and sinister mutations of acute myeloid leukemia (AML), according to researchers. In a first-in-human study, researchers treated relapsed patients with gilteritinib, an FLT3 inhibitor, and found it was a well-tolerated drug that led to frequent and more-sustained-than-expected clinical responses, almost exclusively in patients with this mutation.
Simple method measures how long bacteria can wait out antibiotics
A simple test that measures how long it takes to kill bacteria could help doctors treat strains that are on their way to becoming resistant to antibiotics. If implemented in hospitals' microbiology labs, the test could help guide treatment decisions, and could ultimately reduce the ever-growing risk of bacterial resistance.
Finding the perfect match: New approach to battle drug-resistant bacteria
Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers have now developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections.
African plant extract offers new hope for Alzheimer's
A plant extract used for centuries in traditional medicine in Nigeria could form the basis of a new drug to treat Alzheimer's disease, researchers have found.
Isolating anti-Alzheimer's compounds in plants
Scientists have developed a method to isolate and identify active compounds in plant medicines, which accurately accounts for drug behavior in the body. Using the technique, they have identified several active compounds from Drynaria Rhizome, a traditional plant medicine, which improve memory and reduce disease characteristics in a mouse model of Alzheimer's disease.
Gene variant protecting against Alzheimer's disease decreases plasma beta-amyloid levels
The APP gene variant protecting against Alzheimer’s disease significantly decreases plasma beta-amyloid levels in a population cohort. This is a very significant discovery, as many on-going drug trials in the field of Alzheimer's disease focus on decreasing beta-amyloid levels in the brain tissue. According to the study, a 30% life-long decrease in beta-amyloid levels is not associated with detrimental effects on lipid or glucose metabolism, or on any other metabolic factors.  
Psychiatric medication protects developing mouse brain from birth defects
A clinically available anxiety drug safely and effectively protects against brain defects caused by the mouse version of a common human virus, finds new research.
DNA delivery technology joins battle against drug-resistant bacteria
A new DNA delivery technology has been developed to fight drug-resistant bacteria, report investigators.
Investigation tests drug to activate immune system, help fight cancer
The Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates (ADCs) in Microgravity investigation seeks to activate immunogenic cell death within the cancer cells, which should kill the cancer and prevent the disease from reoccurring in the future.
New genetic technique could help identify potential drug targets for malaria
Scientists have developed a new technique for investigating the effects of gene deletion at later stages in the life cycle of a parasite that causes malaria in rodents, according to a new study. The novel approach could enhance research into potential drug targets for malaria treatment.
New antibiotic effective against drug-resistant bacteria
Scientists have discovered a new antibiotic effective against drug-resistant bacteria: pseudouridimycin. The new antibiotic is produced by a microbe found in a soil sample collected in Italy and was discovered by screening microbes from soil samples. The new antibiotic kills a broad spectrum of drug-sensitive and drug-resistant bacteria in a test tube and cures bacterial infections in mice.
A more safe and efficient means for drug manufacturing
Scientists have developed a system that uses continuous flow technology, instead of a batch-by-batch approach, to produce pharmaceutical compounds, and they used it to manufacture a chemotherapy drug that's currently under evaluation in clinical trials.
High prevalence of CRE in Washington, D.C. healthcare facilities
Carbapenem-resistant Enterobacteriaceae (CRE), a family of highly pathogenic antibiotic-resistant organisms, are endemic across Washington, D.C. healthcare facilities, with 5.2 percent of inpatients testing positive for the bacteria, according to new research.
Inhibitor drug improves overall survival in older radioiodine resistant thyroid cancer
The drug lenvatinib can significantly improve overall survival rates in a group of thyroid cancer patients whose disease is resistant to standard radioiodine treatment, according to new research. The study is the first to show lenvatinib has a definitive impact on overall survival (OS). Researchers found OS improves in patients older than 65 years of age and that the drug is well-tolerated.
Blocking gene expression to combat deadly fungal infection
Deadly fungal infections are becoming resistant to common treatments, but a team of researchers have found a potential new solution.
Reproducing a retinal disease on a chip
Good news for the treatment of retinal diseases using the organ-on-a-chip approach.
A mechanical trigger for toxic tumor therapy
Cell-killing chemotherapies are designed to shrink cancerous tumors by accumulating in their ill-formed blood and lymph vessels, delivering a toxic dose to the cancer cells. Scientists have developed a new drug delivery platform that uses safe, low-energy ultrasound waves to trigger aggregates of chemotherapy-containing nanoparticles to break apart precisely at tumor sites, resulting in dramatically improved targeting efficacy and toxicity profile in mouse models of breast cancer.
Plant compound more powerful than AZT against HIV
A plant found throughout Southeast Asia traditionally used to treat arthritis and rheumatism contains a potent anti-HIV compound more powerful than the drug AZT, according to a new paper.
Antibiotic design strategy boosts odds against resistance development
A new rational drug design technique that uses a powerful computer algorithm to identify molecules that target different receptor sites on key cellular proteins could provide a new weapon in the battle against antibiotic resistance, potentially tipping the odds against the bugs.
Experimental cancer drug shows promise
The drug, geranylgeranyltransferase inhibitor GGTI-2418 suppresses a new defective PTEN cancer pathway, researchers have discovered.
Protein network signals found to drive myeloid leukemias
Researchers have uncovered how mutations in a protein network drive several high-risk leukemias, offering new prospects for novel therapies. An existing drug might be repurposed to treat these leukemias, and the new understanding of the molecular mechanisms at work may offer clues to other drugs yet to be developed.
Anti-malaria drugs: Potential new target identified
A newly described protein could be an effective target for combatting drug-resistant malaria parasites. The protein regulates a number of genes involved with a critical part of the parasite's complex life cycle -- its invasion of a person's red blood cells. Now that the researchers know the protein's role in this invasion process, they have a completely new angle for developing new antimalarial drugs for targeting the malaria parasite.
Major study heralds new era in treatment of type 2 diabetes
A drug that lowers blood sugar levels for people with type 2 diabetes has also been revealed to significantly reduce the risk of both cardiovascular and kidney disease. The study has major implications for the treatment of type 2 diabetes which affects around 450 million people worldwide.
Bacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB
The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic -- produced by bacteria from the lung infection in a cystic fibrosis patient -- could help fight these infections. Lab testing shows that the compound is active against multi-drug resistant strains.
Resistance to targeted therapy in mantle cell lymphoma
A team of cancer researchers have published research looking at the underlying mechanisms of resistance to the drug, Ibrutinib, which is used to treat patients with mantle cell lymphoma.
Diabetes drug trial needs to widen participants to understand full impact of drugs
More work needs to be done to examine the real world effects of the commonly prescribed diabetes drug empagliflozin, new research finds.
Improved accuracy when testing cancer drugs
A method to more accurately test anti-cancer drugs has now been developed, report scientists. The method paves the way to much earlier assessment of who benefits from a specific drug and who does not.
Major new appetite regulator successfully manipulated in mice
A new link between certain brain receptors and obesity has been identified by researchers, giving a possible new drug target for appetite regulation.
Further support for genetic factors underlying addictions
Impairment of a particular gene raises increases susceptibility to opioid addiction liability as well as vulnerability to binge eating according to a new study. Dysfunction of the gene, casein kinase1-epsilon (CSNK1E), increases opioid's euphoric response and produces a marked increase in sensitivity to binge eating in a female experimental model but not in the male.
Hope for better lung cancer treatment on horizon
There is a better way to recruit the right participants for promising new anti-cancer drugs called FGFR (fibroblast growth factor receptor) inhibitors, which are being investigated for treating lung squamous cell carcinoma, outlines a new report.
New cancer drug makes commonly prescribed chemo drug more effective when given together
Researchers have found a way to increase the effectiveness of a widely used cancer drug while decreasing the risk of heart-damaging side effects, according to a new study.
inflammatory molecule essential to muscle regeneration in mice, researchers find
A molecule released as part of an inflammatory response after muscle injury or rigorous exercise activates muscle stem cells responsible for repairing the damage, according to a study.
Researchers identify inhibitor that overcomes drug resistance in prostate cancer
A newly discovered epigenetic mechanism can lead to the development of castration-resistant prostate cancer, new research demonstrates.
Technology unlocks mold genomes for new drugs
Fungi are rich sources of natural molecules for drug discovery, but numerous challenges have pushed pharmaceutical companies away from tapping into this bounty. Now scientists have developed technology that uses genomics and data analytics to efficiently screen for molecules produced by molds to find new drug leads -- maybe even the next penicillin. From three diverse fungal species, the research team discovered 17 new natural products.
Previously unpublished trial data explain effects and side effects of key MS drug
Alemtuzumab is a highly effective drug for multiple sclerosis, approved in more than 60 countries and used by more than 12,000 patients worldwide. However, there is an almost 50 per cent risk of secondary autoimmune diseases, some of which are life-threatening, such as platelet and kidney diseases.
Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells.
Cancer stem cells, which fuel the growth of fatal tumors, can be knocked out by a one-two combination of antibiotics and Vitamin C, report investigators.
Relationship between pain and opioid abuse examined
The drug overdose epidemic is largely driven by opioids, which continue to be prescribed for chronic pain despite recommendations to use non-opioids for most cases.
New cancer drug tested in mice may benefit certain leukemia patients
Up to 30 percent of adult acute lymphoblastic leukemia or ALL patients have Philadelphia chromosome, where two segments of chromosomes have aberrantly fused together. Adult ALL patients often see high relapse rates, and treatment-related deaths remain high. Researchers now report on a study that could provide better therapeutic options for patients.
New study design holds promise for drug safety research
As the pace of drug approvals accelerates and the US Food and Drug Administration (FDA) faces potential budget cuts, a new research design offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use.
Experimental drug BIA 10-2474 deactivates proteins in human nerve cells
At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells.
Heroin's use rising, costing society more than $51 billion
Heroin use in the United States was estimated to cost society more than $51 billion in 2015, according to new research.
New cellular imaging paves way for cancer treatment
Researchers have pioneered a technique which uses florescent imaging to track the actions of key enzymes in cancer, genetic disorders and kidney disease.
Feared by drug users but hard to avoid, fentanyl takes a mounting toll
In a pair of studies of Rhode Island's opioid overdose epidemic, researchers show that while heroin users appear desperate to avoid fentanyl, it's killing more of them every year.
Neurodegenerative disease mechanism and potential drug identified
Two new studies of neurodegenerative diseases linked to mitochondrial defects offer hope for developing a new biomarker for research and diagnostics, and a drug for treating such diseases.
Standard dosage for one lung cancer treatment may be too high
The customary pembrolizumab dose for treatment of metastatic non-small cell lung cancer may be higher than is needed for effective treatment, conclude researchers.
Encouraging results from combination therapy in Hodgkin lymphoma
Combination therapy with brentuximab vedotin and gemcitabine in patients is "highly active" regimen for patients with Hodgkin lymphoma, the authors of a phase II clinical study report.
Targeted therapies show initial effectiveness in subset of papillary thyroid cancer
Two immunotherapy drugs currently approved by the US Food and Drug Administration (FDA) for the treatment of melanoma also show promise for treating a rare but aggressive form of papillary thyroid cancer, according to new research.
Antibiotic-resistant bacteria in ready-to-eat foods
Research shows that antibiotic-resistant bacteria are present in many ready-to-eat foods such as fresh produce and dairy products and may serve as a source of human exposure to antibiotic-resistant bacteria.
Injectable solution may provide weeks of glucose control
Biomedical engineers have created a biopolymer that can provide weeks of glucose control with a single injection. The new tool has the potential to replace daily or weekly insulin shots with bi-weekly or once-a-month treatments of glucagon-like peptide-1 (GLP1) for type 2 diabetes.
Immunotherapy drug effective for metastatic triple negative breast cancer
The immunotherapy drug, Pembrolizumab, is effective in shrinking tumors among metastatic triple negative breast cancer patients as found in a clinical trial.
Bacteria used as factories to produce cancer drugs
Researchers have developed a method of producing P450 enzymes -- used by plants to defend against predators and microbes -- in bacterial cell factories. The process could facilitate the production of large quantities of the enzymes, which are also involved in the biosynthesis of active ingredients of cancer drugs.
Certain vaginal bacteria render HIV microbicide less effective
Certain types of vaginal bacteria rapidly degrade a medication used to prevent HIV, a study of South African women reveals.
Chemists forge a new path in the search for antibiotics
Scientists have developed a novel chemical process that may lead to the creation of a new class of antibiotics. The discovery comes at a time when more types of bacteria are becoming resistant to existing antibiotics, increasing the occurrence of lethal infections. The ability to create new antibiotics would have significant ramifications for medical treatment and public health, said the researchers.
Why antibiotics fail
Biologists have corrected a flaw in the way bacterial susceptibility to antibiotic drugs is tested.
New consensus document for appropriate use of drug testing in clinical addiction medicine
A new Consensus Document from the American Society of Addiction Medicine (ASAM) provides practical, evidence-based recommendations on the use of drug testing for identification, diagnosis, treatment, and monitoring of patients with or at risk for substance use disorders (SUDs).
Scientists discover a new way to target drug-resistant bacteria
A new class of compounds that inhibit bacterial DNA gyrase has been discovered by a team of researchers.
New approach set to make peptide stapling widely available
A new method to structure peptides has now been created, which researchers say will be cheaper and make the process of using stapled peptides in drug discovery much more widely available.
Payments linked to higher odds of doctors prescribing certain cancer drugs
Researchers show that when physicians had to choose between multiple, on-patent drugs for metastatic kidney cancer and chronic myeloid leukemia, they were more likely to prescribe drugs from companies they had received general payments from.
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