NEJM Journal Watch: Oncology And Hematology RSS Feed
Pembrolizumab Added to Chemotherapy Improves Survival in Advanced Esophageal Cancer
The survival benefit may be limited to patients with PD-L1 combined positive scores ≥10%.
HER2 Is a Viable Target in Biliary Tract Cancer
In patients with HER2-positive advanced biliary cancers, an objective response rate of 23% was achieved with HER2-targered therapy.
Distinct Signatures of Lung Cancer Types in Never-Smokers
The genomic landscape of tumors in never-smokers differs substantially from that in smokers.
Higher-Dose Radiotherapy Adds No Benefit in Esophageal Cancer
In patients undergoing primary chemoradiotherapy without surgery, a higher radiation dose conferred no survival benefit over the standard dose.
S-1 and Radiotherapy Effective in Older Patients with Esophageal Cancer
Compared with radiotherapy alone, S-1 chemoradiotherapy improved overall survival and was well tolerated by patients aged 70 to 85 years in this randomized study.
Mycophenolate Mofetil Added to Steroids for Immune Thrombocytopenia
Patients treated with mycophenolate plus steroids had fewer treatment failures but worse quality of life than those treated with steroids alone.
Benefits of Including More Black Individuals in Lung Cancer Screening
In a statistical modeling study, increasing the proportion of Black individuals in the National Lung Screening Trial population increased the relative mortality benefit of low-dose CT screening.
A Novel Immunotherapy for Relapsed or Refractory Myeloma
A bispecific monoclonal antibody targeting the myeloma cell protein BCMA and the T-cell co-receptor CD3 was efficacious in heavily pretreated patients.
Progress in Treatment for Relapsed or Refractory Hodgkin Lymphoma
Overall survival was 93% at 3 years with second-line brentuximab vedotin plus nivolumab followed by autologous stem cell transplantation.
A New Triplet Therapy Option for Multiple Myeloma
Outcomes were improved with the addition of the monoclonal antibody isatuximab to carfilzomib plus dexamethasone in patients with relapsed or refractory disease.
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